The future of immunotherapy in the veterinary space is changing in a great way!
Ashley Kalinauskas, the CEO and Founder of Torigen Pharmaceuticals can't help but think of how many pets they've saved since 2013. Both Kalinauskas and her team are ambitious and ready to continue to improve immunotherapy. Though it can be hard to think about, countless dogs and cats are diagnosed with cancer each year.
For pet owners, that can mean treatment options are limited because the location of veterinary oncologists, and it can cost thousands to get their pets back to their happy, healthy lives. Kalinauskas aims to save our furry friends from cancer and alongside her former professor, who has years of experience in personalized cancer treatments, she decided to make a business plan and bring this technology to market.Now, five years later, Kalinauskas paints a picture of just how much she and her team at Torigen care about the pets they've positively impacted. On the wall of her office, based in Farmington, Connecticut, are a series of photos. Each photo represents the story of a pet that has been treated by Torigen's immunotherapy. “[Pet owners] send us every update; the veterinarians send us pictures and updates," she said. “That means the world to us that every single day we are coming in and we are making a difference." Seeing those pictures, and knowing their work has an impact keeps them going every day.
“That means the world to us, that every single day we are coming in we are making a difference,"
How did it begin?Prior to the creation of Torigen, her former professor's dog developed cancer. It took time, patience and a lot of research to find a way to get rid of the tumor. Fortunately, he was able to treat his dog and was motivated to look into the veterinary market instead of the human one. “Being able to really take a portion of the patient's own tumor and create that into a series of vaccines really [allows] for the stimulation of the immune system," she explained. “When he analyzed his results against multiple tumor models like mammary carcinoma, ovarian, prostate, melanoma, he really saw the same results, that by utilizing an approach like this cancer vaccine, we're able to really drive down the overall rate of metastases, as well as reducing some of that tumor burden. The treatment is not chemotherapy or radiation. It's immunotherapy."[thb_image full_width="true" alignment="center" image="9774" img_size="full"]Torigen has been on a long road to success. From Kalinauskas' graduate thesis project at the University of Notre Dame to becoming a successful company that is getting recognized by leaders in the animal health field. “Building Torigen [was] a lot of hard work," she admitted. “I fell into this… I was doing research and then it became – 'hey, maybe I want to look into applying for the Notre Dame business plan competition." That was just what she did. After putting together a plan, and figuring out the company name, they entered the competition. She remembers it as a yearlong process. “At that point, we still didn't think we had a business," she said. “We thought we had a really great idea." And at that stage, she realized a lot went into building, running a company, and getting something out of the lab and into the market. “It wasn't until we placed second at the competition, and the next day we had a line of investors waiting to meet with us that my professor and I made the decision," she recalled. “We were like 'Alright! [It's] now or never! Are we doing this?' And we both said 'Let's go!'"
Pictured above, Torigen received an investment of $50,000. (Photo courtesy of Ashley Kalinauskas)
“It wasn't until we placed second at the competition, and the next day we had a line of investors waiting to meet with us that my professor and I made the decision," she recalled.From that point on Kalinauskas was “the driver" behind Torigen. “I guess the founding and forming of Torigen was [built on] initiative, drive, and building a really strong team that has brought us to where we are," she shared. Vetivax, or as the CEO refers to as “V-VAX 001," is their product, which can be offered through veterinary clinics.
The experimental autologous cancer vaccine is regulated by the USDA Center for Veterinary Biologics. “We work with veterinarians and after a tumor gets surgically excised a portion can get sent into our laboratories," she explains. “Once here, we create the experimental therapeutic vaccine." Unlike chemotherapy, which Kalinauskas points out can range from $3,000 to $5,000 to start, the Vetivax treatment is about $1,500 through the veterinarian and veterinary clinic.“I guess the founding and forming of Torigen was [built on] initiative, drive, and building a really strong team that has brought us to where we are,"
Out of many recent success stories, there is one story she is constantly reminded of. There was a pet owner who frequently reached out to the Torigen team. “The pet had multiple recurrences of an oral squamous cell carcinoma, [which] was treated by a veterinary surgeon, and I think that we've just reached the date where this pet has exceeded the survival time that is expected," she recounted. In remembrance they had a celebration. “This was a really difficult tumor to treat and especially for what this pet had already gone through before coming to us," she continued. “That pet owner [was] just so happy that there [were] no more recurrences of this tumor after using our treatment."
It is that kind of dedication and care that also led Torigen to win the Animal Health Investment Forum Innovation Award. “That was awarded by the Kansas City Animal Investment Forum by industry leaders in the animal health space." She continued, “I think out of all the awards that we've gotten so far, this one is the one that means the most to us because it's really that stamp of approval by the industry that a company like ours, that's really focused on finding new cancer treatment options in the veterinary market is so needed in this space," she recalled happily. Along with her team, Kalinauskas has used her background in cancer research and cancer immunology, to change the way veterinarians use immunotherapy. “What's inspired me to do what I do is that you know, when you have a love for animals, and you're on the forefront of innovation, how can you make all of those pieces come together to drive and define how humans can be treated with cancer," she voiced.
In the years ahead, two of the main goals at Torigen are: building the team and expanding the company. “We are bringing on additional investment into the company, but what is making me so excited [is], I just finished writing the full outline of the beginning of a really cool grant proposal that we have with some amazing collaborators that I think will really allow us to push the forefront of what's being done on the human side of Immuno-Oncology, how that could be applied to the veterinary space, and how we can really allow it to move faster," Kalinauskas said. She hopes to bridge knowledge between the human market and veterinary market. “Animals, humans aside we both develop cancer [and] tumors," she noted. “Dog tumors are extremely similar to those of humans, so if we can successfully treat cancer in dogs with new modalities and new approaches, how can that research translate over to humans?"
On a personal level, Kalinauskas also hopes to inspire and mentor young women that intern at Torigen. “We have such a fabulous intern program, where interns work with us both in the summer and throughout the year," she said. “I'm excited about the potential for us, this May, to bring on three of those interns as full-time employees." Kalinauskas sees this as an opportunity to help undergrad students grow in their field before pursuing higher education. So far her interns have been women. “They're blowing their male competitors out the water because when there is an internship opportunity, they're hungry and they want it," she said. “If I had somebody that wanted it, regardless of their gender, of course, they would be at the top of my list, and so far it's only been girls." Kalinauskas believes that it not only gives them a strong background in science but also gets them involved in a small business, which allows them to become ingrained in what Torigen does.
For decades, women have been unknowingly suffering from PSD and intergenerational trauma, but now Dr. Valerie Rein wants women to reclaim their power through mind, body and healing tools.
As women, no matter how many accomplishments we have or how successful we look on the outside, we all occasionally hear that nagging internal voice telling us to do more. We criticize ourselves more than anyone else and then throw ourselves into the never-ending cycle of self-care, all in effort to save ourselves from crashing into this invisible internal wall. According to psychologist, entrepreneur and author, Dr. Valerie Rein, these feelings are not your fault and there is nothing wrong with you— but chances are you definitely suffering from Patriarchy Stress Disorder.
Patriarchy Stress Disorder (PSD) is defined as the collective inherited trauma of oppression that forms an invisible inner barrier to women's happiness and fulfillment. The term was coined by Rein who discovered a missing link between trauma and the effects that patriarchal power structures have had on certain groups of people all throughout history up until the present day. Her life experience, in addition to research, have led Rein to develop a deeper understanding of the ways in which men and women are experiencing symptoms of trauma and stress that have been genetically passed down from previously oppressed generations.
What makes the discovery of this disorder significant is that it provides women with an answer to the stresses and trauma we feel but cannot explain or overcome. After being admitted to the ER with stroke-like symptoms one afternoon, when Rein noticed the left side of her body and face going numb, she was baffled to learn from her doctors that the results of her tests revealed that her stroke-like symptoms were caused by stress. Rein was then left to figure out what exactly she did for her clients in order for them to be able to step into the fullness of themselves that she was unable to do for herself. "What started seeping through the tears was the realization that I checked all the boxes that society told me I needed to feel happy and fulfilled, but I didn't feel happy or fulfilled and I didn't feel unhappy either. I didn't feel much of anything at all, not even stress," she stated.
Photo Courtesy of Dr. Valerie Rein
This raised the question for Rein as to what sort of hidden traumas women are suppressing without having any awareness of its presence. In her evaluation of her healing methodology, Rein realized that she was using mind, body and trauma healing tools with her clients because, while they had never experienced a traumatic event, they were showing the tell-tale symptoms of trauma which are described as a disconnect from parts of ourselves, body and emotions. In addition to her personal evaluation, research at the time had revealed that traumatic experiences are, in fact, passed down genetically throughout generations. This was Rein's lightbulb moment. The answer to a very real problem that she, and all women, have been experiencing is intergenerational trauma as a result of oppression formed under the patriarchy.
Although Rein's discovery would undoubtably change the way women experience and understand stress, it was crucial that she first broaden the definition of trauma not with the intention of catering to PSD, but to better identify the ways in which trauma presents itself in the current generation. When studying psychology from the books and diagnostic manuals written exclusively by white men, trauma was narrowly defined as a life-threatening experience. By that definition, not many people fit the bill despite showing trauma-like symptoms such as disconnections from parts of their body, emotions and self-expression. However, as the field of psychology has expanded, more voices have been joining the conversations and expanding the definition of trauma based on their lived experience. "I have broadened the definition to say that any experience that makes us feel unsafe psychically or emotionally can be traumatic," stated Rein. By redefining trauma, people across the gender spectrum are able to find validation in their experiences and begin their journey to healing these traumas not just for ourselves, but for future generations.
While PSD is not experienced by one particular gender, as women who have been one of the most historically disadvantaged and oppressed groups, we have inherited survival instructions that express themselves differently for different women. For some women, this means their nervous systems freeze when faced with something that has been historically dangerous for women such as stepping into their power, speaking out, being visible or making a lot of money. Then there are women who go into fight or flight mode. Although they are able to stand in the spotlight, they pay a high price for it when their nervous system begins to work in a constant state of hyper vigilance in order to keep them safe. These women often find themselves having trouble with anxiety, intimacy, sleeping or relaxing without a glass of wine or a pill. Because of this, adrenaline fatigue has become an epidemic among high achieving women that is resulting in heightened levels of stress and anxiety.
"For the first time, it makes sense that we are not broken or making this up, and we have gained this understanding by looking through the lens of a shared trauma. All of these things have been either forbidden or impossible for women. A woman's power has always been a punishable offense throughout history," stated Rein.
Although the idea of having a disorder may be scary to some and even potentially contribute to a victim mentality, Rein wants people to be empowered by PSD and to see it as a diagnosis meant to validate your experience by giving it a name, making it real and giving you a means to heal yourself. "There are still experiences in our lives that are triggering PSD and the more layers we heal, the more power we claim, the more resilience we have and more ability we have in staying plugged into our power and happiness. These triggers affect us less and less the more we heal," emphasized Rein. While the task of breaking intergenerational transmission of trauma seems intimidating, the author has flipped the negative approach to the healing journey from a game of survival to the game of how good can it get.
In her new book, Patriarchy Stress Disorder: The Invisible Barrier to Women's Happiness and Fulfillment, Rein details an easy system for healing that includes the necessary tools she has sourced over 20 years on her healing exploration with the pioneers of mind, body and trauma resolution. Her 5-step system serves to help "Jailbreakers" escape the inner prison of PSD and other hidden trauma through the process of Waking Up in Prison, Meeting the Prison Guards, Turning the Prison Guards into Body Guards, Digging the Tunnel to Freedom and Savoring Freedom. Readers can also find free tools on Rein's website to help aid in their healing journey and exploration.
"I think of the book coming out as the birth of a movement. Healing is not women against men– it's women, men and people across the gender spectrum, coming together in a shared understanding that we all have trauma and we can all heal."